Affiliation

• Faculty of Pharmacy

Research expertise

• Neuropharmacology
• Parkinson's disease
• Identification and validation of new therapeutic targets
• Antipsychotics
• Dyskinesia

Main research projects

• Identification of lead compounds for modulation of Nur77/RXR receptor complex activity in the management of L-Dopa-induced dyskinesia in Parkinson's disease 
• Implementation of an artificial intelligence approach in drug identification and optimization for the treatment of Parkinson’s disease 
• The role of transcription factors Nur77 and retinoid X receptor (RXR) in the effect of antipsychotic, antiparkinsonian, and abuse drugs 

Approaches used

• Cellular and molecular biology
• Cellular and animal models
• High-throughput screening
• Gene and protein expression
• Transcriptomics and proteomics

Keywords

Dopamine, Nuclear receptors, Movement disorders, Post-translational modifications, Intracellular signaling