Affiliation

• Department of Pharmacology and Physiology  - Faculty of Medicine

Research expertise

• Alzheimer's disease
• Age-related memory deficits
• Amyloid-beta pathology
• Tau pathology
• STEP phosphatase

Main research projects

• Transcriptomic and epigenomic analysis of the various cell types affected by amyloid-beta oligomers in the rat hippocampus
• Impact of amyloid-beta oligomers on glutamate levels and neuronal activity in the rat hippocampus
• Spread and accumulation of tau protein in the mouse hippocampus and entorhinal cortex
• Assessment of memory in mice after deletion or overexpression of STEP phosphatase in the CA2 region of the hippocampus
• Neuroligin-1 as an early blood biomarker of Alzheimer's disease

Approaches used

• Molecular and cellular biology
• Behavioural tests in mice and rats
• Laser microdissection
• Single-nucleus RNA/ATACseq
• CRISPR-Cas9

Keywords

Alzheimer's disease, Memory disorders, Amyloid-beta oligomers, Tau protein, STEP phosphatase