Affiliations

• Department of Pharmacology and Physiology
• Central Nervous System Research Group (GRSNC)
• Research Center of the University Institute of Geriatrics of Montreal (CRIUGM)

Research expertise

• Regulation of cerebral blood flow
• Arterial hypertension
• Menopause and sexual differences
• Neurodegenerative diseases
• Aging

Main research projects

• Canadian Consortium for Neurodegeneration in Aging (CCNA-CCNV) - Team 7.1.2: Effects of arterial stiffness on cerebrovascular and memory deficits in Alzheimer's Disease (the "Sub-project")
• Mechanisms underlying neurovascular coupling
• Sexual differences in brain vulnerability to arterial stiffness
• Development of deep learning-based image analysis and stimulation system applicable to 3D cellular imaging to study the role of neuron-glia interactions and neurovascular coupling in plasticity and learning
• Neurovascular coupling in hypertension

Approaches used

• Measurement of cerebral blood flow in vivo using a laser Doppler probe
• In vivo and in vitro multi-photon microscopy
• Vascular reactivity on isolated arteries
• Immunohistochemistry
• Molecular biology

Keywords

Cerebral blood flow, Arterial hypertension, Sex, Aging, Alzheimer's disease