Affiliations

• Department of Neuroscience - Faculty of Medicine
• Member of the GRSNC

Research expertise

• Organization and function of hippocampal synaptic circuits
• Plasticity of synaptic transmission in learning and memory
• Synaptic dysfunction in brain diseases (autism, intellectual disability, and epilepsy)

Main research projects

• Regulation of the hippocampal network and memory by synaptic plasticity of inhibitory interneurons
• Control of mRNA translation in learning, memory and autism disorders (collaboration N. Sonenberg)
• Heterogeneous regulation of hippocampal inhibitory synapses by astrocytes (collaboration R. Robitaille)
• Dysfunctions of inhibitory interneurons in genetic mouse models of epilepsy (collaboration E. Rossignol)

Approaches used

• Electrophysiology (patch-clamp, field potential) on slices in vitro 
• 2-photon cell imaging (in vitro, in vivo)
• Molecular biology and transgenic mice
• Behavioral tests (learning and memory, virtual reality)
• Optogenetics and chemogenetics

Keywords

Learning and memory, Inhibitory interneurons, Autism, Epilepsy, Hippocampus